{"id":30432,"date":"2022-08-14T11:07:09","date_gmt":"2022-08-14T09:07:09","guid":{"rendered":"https:\/\/www.cmtc.nl\/pedia\/pedia-other\/alpelisib\/"},"modified":"2025-12-07T10:09:21","modified_gmt":"2025-12-07T09:09:21","slug":"alpelisib","status":"publish","type":"page","link":"https:\/\/www.cmtc.nl\/en\/pedia\/treatment\/medication\/alpelisib\/","title":{"rendered":"Alpelisib"},"content":{"rendered":"<p>Novartis\u2019 medicine Vijoice\u00ae (alpelisib) is intended to be used for the treatment of patients with PROS, a spectrum of rare conditions characterized by overgrowths and blood vessel anomalies impacting an estimated 14 people per million. The overgrowth disorders caused by PIK3CA mutations that fall under PROS includes: KTS, CLOVES syndrome, ILM, MCAP\/M-CM, HME, HHML, FIL, FAVA, macrodactyly, muscular HH, FAO, CLAPO syndrome and epidermal nevus, benign lichenoid keratosis or seborrheic keratosis.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Novartis\u2019 medicine Vijoice\u00ae (alpelisib) is intended to be used for the treatment of patients with PROS, a spectrum of rare conditions characterized by overgrowths and blood vessel anomalies impacting an estimated 14 people per million. The overgrowth disorders caused by PIK3CA mutations that fall under PROS includes: KTS, CLOVES syndrome, ILM, MCAP\/M-CM, HME, HHML, FIL, [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":2378,"parent":69494,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"aw-modules\/awcf_create_page_templates_with_elementor_content\/page-templates\/page-aw-page-template-67351.php","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-30432","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Alpelisib - CMTC-OVM<\/title>\n<meta name=\"description\" content=\"Sirolimus, ook wel rapamycine genoemd, is ingezet in een aantal studies bij pati\u00ebnten met ernstige vasculaire malformaties. Het lijkt een gunstig effect te hebben. 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