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Local accumulations of fat cells and abnormalities of blood vessels and/or bones

CLOVES is a rare congenital disorder characterized by localized fat deposits and congenital abnormalities of blood vessels and/or bones.

CLOVES is an abbreviation for Congenital, Lipomatous Overgrowth, Vascular malformations, Epidermal nevi and Scoliosis/Skeletal/Spinal anomalies.

CLOVES is not hereditary and the cause CLOVES is a genetic error in the PIK3ca gene. The diagnosis can be confirmed by performing a PIK3ca test on tissue that has been affected. There is currently no cure for CLOVES.


The symptoms range from mild to severe. Patients often have a combination of abnormalities. The most common features are:

  • Overgrowth of body parts such as legs.
  • Fat accumulation in the body and spinal cord.
  • Blood vessel abnormalities.
  • Abnormalities in the skin (developmental disorder of the epidermis cells) or capillary abnormality.
  • Various abnormalities (eg such as kidney abnormalities) and abnormalities of knee/hip joints.

More information: CLOVES community.

Report international scientific conference PIK3CA related conditions

The CLOVES Syndrome Community has organized an international scientific online conference on October 28 and 29, 2021. Here is the report of this conference.